Research - Phase Angle

Aging patients with cancer have a higher risk of mortality and treatment-associated morbidity than younger patients. Nutrition status may play an important role in cancer mortality. We aimed to evaluate the survival time of elderly patients with colorectal cancer and its association with body mass index (BMI), the patient-generated subjective global assessment (PG-SGA), and phase angle (PA). Materials and Methods: BMI, PG-SGA, and PA were determined for all patients (n = 250) at first assessment.

Progressive loss of muscle mass is a major characteristic of cancer cachexia. Consensus definitions for cachexia provide different options to measure muscle mass. This study describes the effect of different methods to determine muscle mass on the diagnosis of cancer cachexia. In addition, the association of cachexia with other features of cachexia, quality of life, and survival was explored.

Prostate cancer is the leading cause of cancer death in men worldwide. A common problem faced by both clinicians and patients is that prostate malignancy does not cause symptoms until it metastasizes or become locally
advanced. Prostate specific antigen (PSA) one of the important screening tools is controversial as its low predictive value results in high number of unnecessary prostate biopsies.

Physical fitness is important for health and longevity, and it has been argued that measurements should be considered routinely in clinical practice. Yet, many general practioners (GPs) have too little time to engage in discussions around physical activity or fitness, let alone their measurement. However, BIA is a quick and simple measure and, if PhA is predictive of such outcomes, may offer a valuable alternative for GPs and other clinical practitioners. Despite various studies in other specific clinical populations, there is little research considering the typical person at elevatedrisk of cardiometabolic disease or type 2 diabetes who might present to a GP and be referred for exercise. As such, the aim of this study was to examine the predictive value of PhA with respect to these measures in a sample of exercise referral patients.

Bioelectrical impedance analysis (BIA) is a non-invasive and easily applied technique which is now widely used in clinical settings. The measured impedance to an alternating current comprises reactance, due to the presence of cellular interfaces which lead to capacitive effects, and resistance due to the presence of extracellular and intracellular electrolyte.

Phase angle and impedance ratio: Two specular ways to analyze body composition.

Myotonic dystrophy type 1 (DM1) is an inherited muscle disorder characterized by slowly progressive weakness due to muscle degeneration. The Muscular Impairment Rating Scale (MIRS) is validated to assess clinical muscle severity of patients with DM1, although the scale is not sensitive enough to assess disease progression in time intervals fit for clinical trials. The aim of this study was to analyze bioelectrical whole body and arm segmental parameters in patients with DM1 to explore a correlation between bioelectrical impedance analysis (BIA) parameters and disease stage.

In critically ill patients, muscle loss is associated with adverse outcomes. Raw bioelectrical impedance analysis (BIA) parameters (eg, phase angle [PA] and impedance ratio [IR]) have received attention as potential markers of muscularity, nutrition status, and clinical outcomes. Our objective was to test whether PA and IR could be used to assess low muscularity and predict clinical outcomes.

Volume expansion in peritoneal dialysis (PD) patients is associated with left ventricular hypertrophy. The link between inflammation and hypervolemia has not been extensively studied. The aim of this study was to determine if an association exists between hypervolemia and markers of inflammation in PD patients.