Research - Phase Angle

Malignancies of tongue represent one of the greatest management challenges for the head and neck oncologists because of the adverse effects of treatment on oral and pharyngeal functions. Diagnosis at later stages results
in poor treatment outcomes and considerable costs to patients. Bioelectric impedance analysis (BIA)-derived phase angle offers an emerging opportunity to assess prognosis in these malignancies.

A frequent manifestation of advanced lung cancer is malnutrition, timely identification and treatment of which can lead to improved patient outcomes. Bioelectrical impedance analysis (BIA) is an easy-to-use and non-invasive technique to evaluate changes in body composition and nutritional status. We investigated the prognostic role of BIA-derived phase angle in advanced non-small cell lung cancer (NSCLC).

Elevated degree of body fatness and changes in other body composition parameters are known to be common effects of treatment for acute lymphoblastic leukemia (ALL) in children. In order to study peculiarities of somatic growth and development in ALL survivors, we describe the results of BIA body composition analysis of 112 boys and 108 girls aged 5-18 years in remission from ALL (remission time range 1-13 years) compared to data from the same number of age- and sex-matched healthy controls (n=220).

Bioelectrical Impedance (BIA) derived phase angle is increasingly being used as an objective indicator of nutritional status in advanced cancer. Subjective Global Assessment (SGA) is a subjective method of nutritional status. The objective of this study was to investigate the association between BIA derived phase angle and SGA in advanced colorectal cancer.

Currently, over 50 million people worldwide are diagnosed with Alzheimer’s Disease (AD) and more than 16 million Americans suffer from Mild Cognitive Impairment (MCI). Despite unremitting scientific and clinical efforts, there has yet to be therapy that has abated disease progression.

Heart failure (HF) patients with hemodilutional anemia had a worse prognosis than those with true anemia. Volume overload (VO) in anemic patients must be identified in order to select the best treatment.

Poor nutritional status is associated with declining lung function in patients with cystic fibrosis (CF). Phase angle (PhA), is a direct measure of the integrity of the cellular membrane and has been shown to be an important biomarker of cellular health and nutritional status in numerous clinical diseases. Furthermore, PhA reference values for a healthy population, stratified by body mass index (BMI), gender and age, exist, providing a prognostic potential.

Bioelectrical impedance analysis (BIA) provides a simple method to assess changes in body composition. Raw BIA variables such as phase angle provide direct information on cellular mass and integrity, without the assumptions inherent in estimating body compartments, e.g. fat-free mass (FFM). Phase angle is a strong functional and prognostic marker in many disease states, but data in COPD are lacking. Our aims were to describe the measurement of phase angle in patients with stable COPD and determine the construct and discriminate validity of phase angle by assessing its relationship with established markers of function, disease severity and prognosis.

A woman’s risk at birth of having ovarian cancer at some point in her lifetime is 1–1.5% and mortality due to the disease is almost 0.5%. It accounts for 3% of all cancers in females. Despite a low contributory percentage, it remains the fifth leading cause of cancer related death. This is because most ovarian cancers are detected when they have spread beyond the ovary. Bioelectric Impedance Analysis (BIA) affords an emerging opportunity to assess prognosis because of its ability to non invasively assess cell and plasma membrane structure and function by means of phase angle.

Worldwide breast cancer is the most frequently diagnosed life threatening cancer and the leading cause of death in women. Bioelectric impedance analysis (BIA) affords an emerging opportunity to assess prognosis because of its ability to non invasively assess cell and plasma membrane structure and function by means of phase angle.