Research - Multiscan 5000

Bioimpedance spectroscopy (BIS) devices are routinely used in the assessment of breast cancer related lymphedema (BCRL). The equipotential electrode placement is a commonly used protocol for the assessment of BCRL. However, the sternal notch electrode placement protocol is also in use. Whether these two protocols are interchangeable is not known.

Critically ill patients retain fluid, up to 30 litres and more. In individuals ill for prolonged periods it is virtually impossible to assess fluid balance accurately, but as a non-invasive method of doing so bioimpedance has its obvious attractions. We have previously described the use of single frequency (50kHz) impedance to assess body water in these individuals but the interindividual errors were too large to be acceptable (Foley et al. 1998). The correlation ® between conductace (height²/impedance) at multiple frequencies (5-500 kHz; Multiscan 5000, Bodystat Ltd, Douglas, Isle of Man) and body water (measured using deuterium analysed by Continuous Flow Isotope Ratio Mass Spectrometry following equilibration with H2) was investigated in ten critically ill patients; in three patients multiple measurements were made, in two on four occasions and in one on six.

Loss of muscle mass is a key characteristic of malnutrition. Bioimpedance is an available technology capable of generating measures of lean tissue at the bed-side. We compared the utility of two different bioimpedance approaches, multiple-frequency bioelectrical impedance analysis (MF-BIA) and bioimpedance spectroscopy (BIS) in head and neck cancer (HNC) patients. Variables of interest were 50 kHz phase angle (PA), 200 kHz/5 kHz impedance ratio (IR), fat-free mass (FFM), total body water (TBW), extracellular water (ECW), and the ratio of ECW/TBW.

The aim of this study was to evaluate changes in body fat stores in major burn injuries as determined by bioelectrical impedance. Nutritional needs directing the provided diet was assessed by indirect calorimetry.

Adequate hydration is crucial in maintaining optimal physical and mental functioning and the need for a fast and reliable hydration status assessment in behavioral medicine research has become increasingly important. The goal of this study was to determine the reliability of bioelectrical impedance assessment (BIA) in assessing total body water (TBW), extracellular water (ECW) and intracellular water (ICW) and to assess whether individuals can be reliably classified as being hypohydrated or hyperhydrated using lower and upper quartiles, respectively.

Phase angle and impedance ratio: Two specular ways to analyze body composition.

Myotonic dystrophy type 1 (DM1) is an inherited muscle disorder characterized by slowly progressive weakness due to muscle degeneration. The Muscular Impairment Rating Scale (MIRS) is validated to assess clinical muscle severity of patients with DM1, although the scale is not sensitive enough to assess disease progression in time intervals fit for clinical trials. The aim of this study was to analyze bioelectrical whole body and arm segmental parameters in patients with DM1 to explore a correlation between bioelectrical impedance analysis (BIA) parameters and disease stage.