The Diab-spot features the AGE measurement and combines this with a small number of person characteristics to calculate the Diab-spot test result.
About AGEs (Advanced Glycation Endproducts)
AGEs play a key role in the development of diabetes and its complications. The level of AGEs in tissues with slow turnover (not in blood) serves as a memory of glycometabolic stress and is a valuable predictor of (pre)diabetes and cardiovascular complications.
AGEs normally accumulate over a person’s lifetime, but this process occurs more rapidly in patients with (pre)diabetes.
Tissue AGEs correlate closely with and are predictors of early kidney, eye and nerve disease in patients with diabetes mellitus.
Moreover they are valuable predictors of future cardiovascular morbidity and mortality.
AGEs are considered to be a major target in the treatment of diabetes and cardiovascular disease.